Blar i forfatter "Haraldsen, Guttorm"

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    • Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients 

      Pihlstrøm, Hege; Ueland, Thor; Michelsen, Annika; Aukrust, Pål; Gatti, Francesca; Hammarström, Clara Louise; Kasprzycka, Monika; Wang, Junbai; Haraldsen, Guttorm; Mjøen, Geir; Dahle, Dag Olav; Midtvedt, Karsten; Eide, Ivar Anders; Hartmann, Anders; Holdaas, Hallvard (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-16)
      Following a successful renal transplantation circulating markers of inflammation may remain elevated, and systemic inflammation is associated with worse clinical outcome in renal transplant recipients (RTRs). Vitamin D-receptor (VDR) activation is postulated to modulate inflammation and endothelial function. We aimed to explore if a synthetic vitamin D, paricalcitol, could influence systemic ...

    • Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis 

      Gundersen, Mona Dixon; Larsen, Kenneth Bowitz; Johnsen, Kay-Martin; Goll, Rasmus; Florholmen, Jon; Haraldsen, Guttorm (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)
      Epithelial alarmins are gaining interest as therapeutic targets for chronic infammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator of the infammatory cascade. However, it is not clear what signals drive the expression of IL-33 in the colonic mucosa, nor is the exact role of IL-33 elucidated. We ...

    • Loss of interleukin 33 expression in colonic crypts- a potential marker for disease remission in ulcerative colitis 

      Gundersen, Mona Dixon; Goll, Rasmus; Hol, Johanna; Olsen, Trine; Rismo, Renathe; Sørbye, Sveinung Wergeland; Sundnes, Olav; Haraldsen, Guttorm; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-17)
      Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer ...

    • Rapid systemic surge of IL-33 after severe human trauma: a prospective observational study 

      Sundnes, Olav; Ottestad, William Arne; Schjalm, Camilla; Lundbäck, Peter; La Cour Poulsen, Lars; Mollnes, Tom Eirik; Haraldsen, Guttorm; Eken, Torsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-26)
      Background - Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In this study we explored high-resolution concentration kinetics of the alarmin interleukin-33 (IL-33) early after human trauma.<p> <p>Methods - ...